Development of a novel PROTAC using the nucleic acid aptamer as a targeting ligand for tumor selective degradation of nucleolin
PROteolysis TArgeting Chimeras (PROTACs) induce targeted protein degradation by hijacking the intracellular ubiquitin proteasome system, thus emerging as a new strategy for drug development. However, most PROTACs generated lack cell-type selectivity and are poorly soluble in water. To address this d...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2022-12-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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