Therapeutic Drug Monitoring and Individualized Medicine of Dasatinib: Focus on Clinical Pharmacokinetics and Pharmacodynamics

• Principais autores: Shiyu He (Autor), Jialu Bian (Autor), Qianhang Shao (Autor), Ying Zhang (Autor), Xu Hao (Autor), Xingxian Luo (Autor), Yufei Feng (Autor), Lin Huang (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Dasatinib is an oral second-generation tyrosine kinase inhibitor known to be used widely in Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL). Notably, although a high pharmacokinetic variability in patients and an increased risk of pleu...