Modelling the Effect of Process Parameters on the Wet Extrusion and Spheronisation of High-Loaded Nicotinamide Pellets Using a Quality by Design Approach

• Главные авторы: Eva-Maria Theismann (Автор), Julia K. Keppler (Автор), Martin Owen (Автор), Karin Schwarz (Автор), Walkiria Schlindwein (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2019-04-01T00:00:00Z.
• Предметы: article
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The aim of the present study was to develop an alternative process to spray granulation in order to prepare high loaded spherical nicotinamide (NAM) pellets by wet extrusion and spheronisation. Therefore, a quality by design approach was implemented to model the effect of the process parameters of t...