Pre-clinical antigenicity studies of an innovative multivalent vaccine for human visceral leishmaniasis.

• Main Authors: Pedro Cecílio (Author), Begoña Pérez-Cabezas (Author), Laura Fernández (Author), Javier Moreno (Author), Eugenia Carrillo (Author), José M Requena (Author), Epifanio Fichera (Author), Steven G Reed (Author), Rhea N Coler (Author), Shaden Kamhawi (Author), Fabiano Oliveira (Author), Jesus G Valenzuela (Author), Luigi Gradoni (Author), Reinhard Glueck (Author), Gaurav Gupta (Author), Anabela Cordeiro- (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The notion that previous infection by Leishmania spp. in endemic areas leads to robust anti-Leishmania immunity, supports vaccination as a potentially effective approach to prevent disease development. Nevertheless, to date there is no vaccine available for human leishmaniasis. We optimized and asse...