Abscisic Acid and Its Receptors LANCL1 and LANCL2 Control Cardiomyocyte Mitochondrial Function, Expression of Contractile, Cytoskeletal and Ion Channel Proteins and Cell Proliferation via ERRα

• Main Authors: Sonia Spinelli (Author), Lucrezia Guida (Author), Mario Passalacqua (Author), Mirko Magnone (Author), Vanessa Cossu (Author), Gianmario Sambuceti (Author), Cecilia Marini (Author), Laura Sturla (Author), Elena Zocchi (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cross-kingdom stress hormone abscisic acid (ABA) and its mammalian receptors LANCL1 and LANCL2 regulate the response of cardiomyocytes to hypoxia by activating NO generation. The overexpression of LANCL1/2 increases transcription, phosphorylation and the activity of eNOS and improves cell vitali...