Leptin counteracts hypothermia in hypothyroidism through its pyrexic effects and by stabilizing serum thyroid hormone levels

• Main Authors: Juliane Weiner (Author), Lisa Roth (Author), Mathias Kranz (Author), Peter Brust (Author), Anita Boelen (Author), Nora Klöting (Author), John T. Heiker (Author), Matthias Blüher (Author), Anke Tönjes (Author), Paul T. Pfluger (Author), Michael Stumvoll (Author), Jens Mittag (Author), Kerstin Krause (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Thyroid hormones (TH) are essential for the homeostatic control of energy metabolism and the regulation of body temperature. The hypothalamic-pituitary-thyroid (HPT) axis is regulated by negative feedback mechanisms, ensuring that TH levels are maintained at a constant level. However, the...