A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors

• Main Authors: Paweletz Cloud (Author), Nagashima Kumiko (Author), Andersen Jannik (Author), Haines Brian (Author), Chenard Melissa (Author), Zhang Theresa (Author), Roberts Brian (Author), Arthur William (Author), Chastain Michael (Author), Frazier Jason (Author), Klinghoffer Rich (Author), Nebozhyn Michael (Author), Loboda Andrey (Author), Lynch Bethany (Author), Feldman Igor (Author), Dai Hongyue (Author), Huang Pearl (Author), Watters James (Author)
• Format: Book
• Published: BMC, 2010-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Hyperactivation of the Ras signaling pathway is a driver of many cancers, and RAS pathway activation can predict response to targeted therapies. Therefore, optimal methods for measuring Ras pathway activation are critical. The main f...