Highly expressed SERCA2 triggers tumor cell autophagy and is a druggable vulnerability in triple-negative breast cancer

• Main Authors: Minmin Fan (Author), Jian Gao (Author), Lin Zhou (Author), Wenwen Xue (Author), Yixuan Wang (Author), Jingwei Chen (Author), Wuhao Li (Author), Ying Yu (Author), Bo Liu (Author), Yan Shen (Author), Qiang Xu (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chemoresistance remains a major obstacle to successful treatment of triple negative breast cancer (TNBC). Identification of druggable vulnerabilities is an important aim for TNBC therapy. Here, we report that SERCA2 expression correlates with TNBC progression in human patients, which promotes TNBC c...