Cu(ATSM) Increases P-Glycoprotein Expression and Function at the Blood-Brain Barrier in C57BL6/J Mice

• Main Authors: Jae Pyun (Author), HuiJing Koay (Author), Pranav Runwal (Author), Celeste Mawal (Author), Ashley I. Bush (Author), Yijun Pan (Author), Paul S. Donnelly (Author), Jennifer L. Short (Author), Joseph A. Nicolazzo (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

P-glycoprotein (P-gp), expressed at the blood-brain barrier (BBB), is critical in preventing brain access to substrate drugs and effluxing amyloid beta (Aβ), a contributor to Alzheimer's disease (AD). Strategies to regulate P-gp expression therefore may impact central nervous system (CNS) drug...