Design, Synthesis, and Development of pyrazolo[1,5-<i>a</i>]pyrimidine Derivatives as a Novel Series of Selective PI3K<i>δ</i> Inhibitors: Part I-Indole Derivatives

• Main Authors: Mariola Stypik (Author), Marcin Zagozda (Author), Stanisław Michałek (Author), Barbara Dymek (Author), Daria Zdżalik-Bielecka (Author), Maciej Dziachan (Author), Nina Orłowska (Author), Paweł Gunerka (Author), Paweł Turowski (Author), Joanna Hucz-Kalitowska (Author), Aleksandra Stańczak (Author), Paulina Stańczak (Author), Krzysztof Mulewski (Author), Damian Smuga (Author), Filip Stefaniak (Author), Lidia Gurba-Bryśkiewicz (Author), Arkadiusz Leniak (Author), Zbigniew Ochal (Author), Mateusz Mach (Author), Karolina Dzwonek (Author), Monika Lamparska-Przybysz (Author), Krzysztof Dubiel (Author), Maciej Wieczorek (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phosphoinositide 3-kinase <i>δ</i> (PI3K<i>δ</i>), a member of the class I PI3K family, is an essential signaling biomolecule that regulates the differentiation, proliferation, migration, and survival of immune cells. The overactivity of this protein causes cellular dysfuncti...