Design, synthesis and biological evaluation of novel O-substituted tryptanthrin oxime derivatives as c-Jun N-terminal kinase inhibitors

Design, synthesis and biological evaluation of novel O-substituted tryptanthrin oxime derivatives as c-Jun N-terminal kinase inhibitors

The c-Jun N-terminal kinase (JNK) family includes three proteins (JNK1-3) that regulate many physiological processes, including inflammatory responses, morphogenesis, cell proliferation, differentiation, survival, and cell death. Therefore, JNK represents an attractive target for therapeutic interve...

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Main Authors: Igor A. Schepetkin (Author), Anastasia R. Kovrizhina (Author), Ksenia S. Stankevich (Author), Andrei I. Khlebnikov (Author), Liliya N. Kirpotina (Author), Mark T. Quinn (Author), Matthew J. Cook (Author)
Format: Book
Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
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3rd Floor Main Library

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