Interleukin-18 Increases TLR4 and Mannose Receptor Expression and Modulates Cytokine Production in Human Monocytes

• Main Authors: Luciane Alarcão Dias-Melicio (Author), Reginaldo Keller Fernandes (Author), Daniela Ramos Rodrigues (Author), Marjorie Assis Golim (Author), Angela Maria Victoriano Campos Soares (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interleukin-18 is a proinflammatory cytokine belonging to the interleukin-1 family of cytokines. This cytokine exerts many unique biological and immunological effects. To explore the role of IL-18 in inflammatory innate immune responses, we investigated its impact on expression of two toll-like rece...