Involvement of the Na+/Ca2+ Exchanger in Ouabain-Induced Inotropy and Arrhythmogenesis in Guinea-Pig Myocardium as Revealed by SEA0400

• Main Authors: Hikaru Tanaka (Author), Hideaki Shimada (Author), Iyuki Namekata (Author), Toru Kawanishi (Author), Naoko Iida-Tanaka (Author), Koki Shigenobu (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Involvement of the Na+/Ca2+ exchanger in ouabain-induced inotropy and arrhythmogenesis was examined with a specific inhibitor, SEA0400. In right ventricular papillary muscle isolated from guinea-pig ventricle, 1 µM SEA0400, which specifically inhibits the Na+/Ca2+ exchanger by 80%, reduced the ouaba...