Involvement of the Na+/Ca2+ Exchanger in Ouabain-Induced Inotropy and Arrhythmogenesis in Guinea-Pig Myocardium as Revealed by SEA0400
Involvement of the Na+/Ca2+ exchanger in ouabain-induced inotropy and arrhythmogenesis was examined with a specific inhibitor, SEA0400. In right ventricular papillary muscle isolated from guinea-pig ventricle, 1 µM SEA0400, which specifically inhibits the Na+/Ca2+ exchanger by 80%, reduced the ouaba...
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| Main Authors: | , , , , , |
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Elsevier,
2007-01-01T00:00:00Z.
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| 001 | doaj_4de9e791e82542e2ba5eaf8f76f325e6 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Hikaru Tanaka |e author |
| 700 | 1 | 0 | |a Hideaki Shimada |e author |
| 700 | 1 | 0 | |a Iyuki Namekata |e author |
| 700 | 1 | 0 | |a Toru Kawanishi |e author |
| 700 | 1 | 0 | |a Naoko Iida-Tanaka |e author |
| 700 | 1 | 0 | |a Koki Shigenobu |e author |
| 245 | 0 | 0 | |a Involvement of the Na+/Ca2+ Exchanger in Ouabain-Induced Inotropy and Arrhythmogenesis in Guinea-Pig Myocardium as Revealed by SEA0400 |
| 260 | |b Elsevier, |c 2007-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.FP0060911 | ||
| 520 | |a Involvement of the Na+/Ca2+ exchanger in ouabain-induced inotropy and arrhythmogenesis was examined with a specific inhibitor, SEA0400. In right ventricular papillary muscle isolated from guinea-pig ventricle, 1 µM SEA0400, which specifically inhibits the Na+/Ca2+ exchanger by 80%, reduced the ouabain (1 µM)-induced positive inotropy by 40%, but had no effect on the inotropy induced by 100 µM isobutyl methylxantine. SEA0400 significantly inhibited the contracture induced by low Na+ solution. In HEK293 cells expressing the Na+/Ca2+ exchanger, 1 µM ouabain induced an increase in intracellular Ca2+, which was inhibited by SEA0400. The arrhythmic contractions induced by 3 µM ouabain were significantly reduced by SEA0400. These results provide pharmacological evidence that the Na+/Ca2+ exchanger is involved in ouabain-induced inotropy and arrhythmogenesis. Keywords:: ouabain, Na+/Ca2+ exchanger, SEA0400, inotropy, arrhythmia | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 103, Iss 2, Pp 241-246 (2007) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319343300 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/4de9e791e82542e2ba5eaf8f76f325e6 |z Connect to this object online. |