Association of obesity risk SNPs in <it>PCSK1 </it>with insulin sensitivity and proinsulin conversion

• Main Authors: Häring Hans-Ulrich (Author), Staiger Harald (Author), Stefan Norbert (Author), Machicao Fausto (Author), Thamer Claus (Author), Ketterer Caroline (Author), Schäfer Silke A (Author), Haupt Axel (Author), Heni Martin (Author), Fritsche Andreas (Author)
• Format: Book
• Published: BMC, 2010-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Prohormone convertase 1 is involved in maturation of peptides. Rare mutations in gene <it>PCSK1</it>, encoding this enzyme, cause childhood obesity and abnormal glucose homeostasis with elevated proinsulin concentrations....