Association of obesity risk SNPs in <it>PCSK1 </it>with insulin sensitivity and proinsulin conversion

• Główni autorzy: Häring Hans-Ulrich (Autor), Staiger Harald (Autor), Stefan Norbert (Autor), Machicao Fausto (Autor), Thamer Claus (Autor), Ketterer Caroline (Autor), Schäfer Silke A (Autor), Haupt Axel (Autor), Heni Martin (Autor), Fritsche Andreas (Autor)
• Format: Książka
• Wydane: BMC, 2010-06-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Prohormone convertase 1 is involved in maturation of peptides. Rare mutations in gene <it>PCSK1</it>, encoding this enzyme, cause childhood obesity and abnormal glucose homeostasis with elevated proinsulin concentrations....