Adenosine Increases the Immunosuppressive Capacity of Cervical Cancer Cells by Increasing PD-L1 Expression and TGF-β Production through Its Interaction with A_2AR/A_2BR

• Main Authors: Rosario García-Rocha (Author), Alberto Monroy-García (Author), Ana Luisa Vázquez-Cruz (Author), Luis Antonio Marín-Aquino (Author), Benny Weiss-Steider (Author), Jorge Hernández-Montes (Author), Christian Azucena Don-López (Author), Gabriela Molina-Castillo (Author), María de Lourdes Mora-García (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study provides evidence showing that adenosine (Ado) increases the expression of programmed death ligand 1 (PD-L1) in cervical cancer (CeCa) cells by interacting with A_2AR/A_2BR and that TGF-β1 acts in an autocrine manner to induce PD-L1 expre...