Modulation of miR-26a-5p and miR-15b-5p Exosomal Expression Associated with Clopidogrel-Induced Hepatotoxicity in HepG2 Cells

• Main Authors: Renata C. Costa de Freitas (Author), Raul H. Bortolin (Author), Mariana B. Lopes (Author), Letícia Tamborlin (Author), Letícia Meneguello (Author), Vivian N. Silbiger (Author), Rosario D. C. Hirata (Author), Mário H. Hirata (Author), Augusto D. Luchessi (Author), André D. Luchessi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clopidogrel is an essential antiplatelet drug used to prevent thrombosis complications associated with atherosclerosis. However, hepatotoxicity is a potential adverse effect related to clopidogrel therapy. Exosome-derived miRNAs may be useful for improved monitoring of drug response and hepatotoxici...