Ergothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons

• Main Authors: Damien Meng-Kiat Leow (Author), Irwin Kee-Mun Cheah (Author), Lucrecia Chen (Author), Yang-Kai Ng (Author), Crystal Jing-Jing Yeo (Author), Barry Halliwell (Author), Wei-Yi Ong (Author)
• Format: Book
• Published: MDPI AG, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cell death involving oxidative stress and mitochondrial dysfunction is a major cause of dopaminergic neuronal loss in the substantia nigra (SN) of Parkinson's disease patients. Ergothioneine (ET), a natural dietary compound, has been shown to have cytoprotective functions, but neuroprotective a...