Ergothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons

• Autori principali: Damien Meng-Kiat Leow (Autore), Irwin Kee-Mun Cheah (Autore), Lucrecia Chen (Autore), Yang-Kai Ng (Autore), Crystal Jing-Jing Yeo (Autore), Barry Halliwell (Autore), Wei-Yi Ong (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2024-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Cell death involving oxidative stress and mitochondrial dysfunction is a major cause of dopaminergic neuronal loss in the substantia nigra (SN) of Parkinson's disease patients. Ergothioneine (ET), a natural dietary compound, has been shown to have cytoprotective functions, but neuroprotective a...