Characterizing the reproducibility in using a liver microphysiological system for assaying drug toxicity, metabolism, and accumulation

• Main Authors: Andrés Rubiano (Author), Amruta Indapurkar (Author), Ryosuke Yokosawa (Author), Alina Miedzik (Author), Barry Rosenzweig (Author), Ayesha Arefin (Author), Chloe M. Moulin (Author), Keri Dame (Author), Neil Hartman (Author), Donna A. Volpe (Author), Murali K. Matta (Author), David J. Hughes (Author), David G. Strauss (Author), Tomasz Kostrzewski (Author), Alexandre J. S. Ribeiro (Author)
• Format: Book
• Published: Wiley, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Liver microphysiological systems (MPSs) are promising models for predicting hepatic drug effects. Yet, after a decade since their introduction, MPSs are not routinely used in drug development due to lack of criteria for ensuring reproducibility of results. We characterized the feasibility o...