Tumor immune microenvironment and apoptotic markers in breast cancer patients carrying <I>BRCA1</I> gene mutations

• Main Authors: A. I. Stukan (Author), A. Yu. Goryainova (Author), O. Yu. Chukhray (Author), S. D. Maksimenko (Author), E. N. Imyanitov (Author), S. V. Sharov (Author), Z. K. Khachmamuk (Author)
• Format: Book
• Published: ABV-press, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. It is suggested that defects in BRCA1 / 2 genes contribute to a high mutational load and high immunogenicity, which modulates immune microenvironment. At the same time, it was shown that BRCA1 / 2-associated breast cancer tumors do not belong to the category of immunoactive ones. These t...