Targeting the Wolbachia cell division protein FtsZ as a new approach for antifilarial therapy.

• Main Authors: Zhiru Li (Author), Amanda L Garner (Author), Christian Gloeckner (Author), Kim D Janda (Author), Clotilde K Carlow (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of antibiotics targeting the obligate bacterial endosymbiont Wolbachia of filarial parasites has been validated as an approach for controlling filarial infection in animals and humans. Availability of genomic sequences for the Wolbachia (wBm) present in the human filarial parasite Brugia mal...