SPHK Inhibitors and Zoledronic Acid Suppress Osteoclastogenesis and Wear Particle-Induced Osteolysis

• Main Authors: Minghui Gu (Author), Baiqi Pan (Author), Weishen Chen (Author), Hai Xu (Author), Xiaoyu Wu (Author), Xuantao Hu (Author), Linli Zheng (Author), Yongyu Ye (Author), Qing Meng (Author), Guoyan Xian (Author), Ziji Zhang (Author), Puyi Sheng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Inflammatory osteolysis induced by wear particles is the major cause of prosthetic loosening after artificial joint replacement, and its prevention and treatment are difficult worldwide. Our previous study confirmed that sphingosine kinases (SPHKs) are important mediators regulating the...