An improved method for large scale generation and high-throughput functional characterization of human iPSC-derived microglia

• Autores principales: Manisha Padmakumar (Autor), Steven Biesmans (Autor), Jorge S. Valadas (Autor), Jan R. Detrez (Autor), Gaëlle Gillet (Autor), Priscillia Bresler (Autor), Marie-Laure Clénet (Autor), Irena Kadiu (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Neuroscience drug discovery has faced significant challenges due to restricted access to relevant human cell models and limited translatability of existing preclinical findings to human pathophysiology. Induced pluripotent stem cells (iPSCs) have emerged as a promising solution, offering the potenti...