Metformin Restores the Drug Sensitivity of MCF-7 Cells Resistant Derivates via the Cooperative Modulation of Growth and Apoptotic-Related Pathways

• Main Authors: Danila Sorokin (Author), Yuri Shchegolev (Author), Alexander Scherbakov (Author), Oxana Ryabaya (Author), Margarita Gudkova (Author), Lev Berstein (Author), Mikhail Krasil'nikov (Author)
• Format: Book
• Published: MDPI AG, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The phenomenon of the primary or acquired resistance of cancer cells to antitumor drugs is among the key problems of oncology. For breast cancer, the phenomenon of the resistance to hormonal or target therapy may be based on the numerous mechanisms including the loss or mutation of estrogen receptor...