Kinin B1 receptor antagonism is equally efficient as angiotensin receptor 1 antagonism in reducing renal fibrosis in experimental obstructive nephropathy, but is not additive.

• Main Authors: Antoine eHuart (Author), Julie eKlein (Author), Julien eGonzalez (Author), Bénedicte eBuffin-Meyer (Author), Eric eNeau (Author), Christine eDelage (Author), Denis eCalise (Author), David eRibes (Author), Joost-Peter eSchanstra (Author), Jean-Loup eBascands (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Renal tubulointerstitial fibrosis is the pathological hallmark of chronic kidney disease. Currently, inhibitors of the renin angiotensin system (RAS) remain the sole therapy in human displaying antifibrotic properties. Further antifibrotic molecules are needed. We have recently reported...