Low-dose nafamostat mesilate ameliorates tissue injury and inhibits 5-hydroxytryptamine synthesis in the rat intestine after methotrexate administration

• Main Authors: Takahiro Yamamoto (Author), Takuji Machida (Author), Chiho Tanno (Author), Shiori Hasebe (Author), Mayu Tamura (Author), Nanaka Kobayashi (Author), Sachiko Hiraide (Author), Naoya Hamaue (Author), Kenji Iizuka (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We aimed to clarify the effect of nafamostat mesilate (nafamostat) on intestinal mucositis as well as the potentiation of intestinal 5-hydroxytryptamine (5-HT) dynamics induced by methotrexate, an anti-cancer drug, in rats. Rats received intraperitoneal methotrexate at 12.5 mg/kg/day for 4 days. In...