Low-dose nafamostat mesilate ameliorates tissue injury and inhibits 5-hydroxytryptamine synthesis in the rat intestine after methotrexate administration

• Hlavní autoři: Takahiro Yamamoto (Autor), Takuji Machida (Autor), Chiho Tanno (Autor), Shiori Hasebe (Autor), Mayu Tamura (Autor), Nanaka Kobayashi (Autor), Sachiko Hiraide (Autor), Naoya Hamaue (Autor), Kenji Iizuka (Autor)
• Médium: Kniha
• Vydáno: Elsevier, 2023-06-01T00:00:00Z.
• Témata: article
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We aimed to clarify the effect of nafamostat mesilate (nafamostat) on intestinal mucositis as well as the potentiation of intestinal 5-hydroxytryptamine (5-HT) dynamics induced by methotrexate, an anti-cancer drug, in rats. Rats received intraperitoneal methotrexate at 12.5 mg/kg/day for 4 days. In...