Low-dose nafamostat mesilate ameliorates tissue injury and inhibits 5-hydroxytryptamine synthesis in the rat intestine after methotrexate administration

• Auteurs principaux: Takahiro Yamamoto (Auteur), Takuji Machida (Auteur), Chiho Tanno (Auteur), Shiori Hasebe (Auteur), Mayu Tamura (Auteur), Nanaka Kobayashi (Auteur), Sachiko Hiraide (Auteur), Naoya Hamaue (Auteur), Kenji Iizuka (Auteur)
• Format: Livre
• Publié: Elsevier, 2023-06-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

We aimed to clarify the effect of nafamostat mesilate (nafamostat) on intestinal mucositis as well as the potentiation of intestinal 5-hydroxytryptamine (5-HT) dynamics induced by methotrexate, an anti-cancer drug, in rats. Rats received intraperitoneal methotrexate at 12.5 mg/kg/day for 4 days. In...