Sepsis Induces a Dysregulated Neutrophil Phenotype That Is Associated with Increased Mortality

• Main Authors: Jaimin M. Patel (Author), Elizabeth Sapey (Author), Dhruv Parekh (Author), Aaron Scott (Author), Davinder Dosanjh (Author), Fang Gao (Author), David R. Thickett (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Neutrophil dysfunction in sepsis has been implicated in the pathogenesis of multiorgan failure; however, the role of neutrophil extracellular traps (NETs) remains uncertain. We aimed to determine the sequential changes in ex vivo NETosis and its relationship with mortality in patients wi...