Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors

• Main Authors: Liying Ma (Author), Haojie Wang (Author), Yinghua You (Author), Chaoya Ma (Author), Yuejiao Liu (Author), Feifei Yang (Author), Yichao Zheng (Author), Hongmin Liu (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Histone lysine specific demethylase 1 (LSD1) has become a potential therapeutic target for the treatment of cancer. Discovery and develop novel and potent LSD1 inhibitors is a challenge, although several of them have already entered into clinical trials. Herein, for the first time, we reported the d...