Trimethylamine N-Oxide Promotes Autoimmunity and a Loss of Vascular Function in Toll-like Receptor 7-Driven Lupus Mice

• Main Authors: Cristina González-Correa (Author), Javier Moleón (Author), Sofía Miñano (Author), Néstor de la Visitación (Author), Iñaki Robles-Vera (Author), Manuel Gómez-Guzmán (Author), Rosario Jiménez (Author), Miguel Romero (Author), Juan Duarte (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Plasma levels of trimethylamine N-oxide (TMAO) are elevated in lupus patients. We analyzed the implication of TMAO in autoimmunity and vascular dysfunction of the murine model of systemic lupus erythematosus (SLE) induced by the activation of the Toll-like receptor (TLR)7 with imiquimod (IMQ). Femal...