Trimethylamine N-Oxide Promotes Autoimmunity and a Loss of Vascular Function in Toll-like Receptor 7-Driven Lupus Mice

• Главные авторы: Cristina González-Correa (Автор), Javier Moleón (Автор), Sofía Miñano (Автор), Néstor de la Visitación (Автор), Iñaki Robles-Vera (Автор), Manuel Gómez-Guzmán (Автор), Rosario Jiménez (Автор), Miguel Romero (Автор), Juan Duarte (Автор)
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• Опубликовано: MDPI AG, 2021-12-01T00:00:00Z.
• Предметы: article
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Plasma levels of trimethylamine N-oxide (TMAO) are elevated in lupus patients. We analyzed the implication of TMAO in autoimmunity and vascular dysfunction of the murine model of systemic lupus erythematosus (SLE) induced by the activation of the Toll-like receptor (TLR)7 with imiquimod (IMQ). Femal...