Pathophysiological Response to Hypoxia - From the Molecular Mechanisms of Malady to Drug Discovery: Hypoxia-Inducible Factor-1 (HIF-1)-Active Cells as a Target for Cancer Therapy

The microenvironment of solid tumors is characterized by low pO2 that is well below physiological levels. Intratumoral hypoxia is a major factor contributing to cancer progression and is exacerbated as a result of oxygen consumption by rapidly proliferating tumor cells near blood vessels, poor lymph...

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Main Authors: Shinae Kizaka-Kondoh (Author), Takahiro Kuchimaru (Author), Tetsuya Kadonosono (Author)
Format: Book
Published: Elsevier, 2011-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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