Pregnane X receptor activation promotes hematopoiesis during liver regeneration by inducing proliferation of hematopoietic stem and progenitor cells in mice

• Main Authors: Shuang Hu (Author), Chenghua Wu (Author), Dan Li (Author), Xiaowen Jiang (Author), Peng Wang (Author), Guofang Bi (Author), Hui Ouyang (Author), Fengting Liang (Author), Wenhong Zhou (Author), Xiao Yang (Author), Jian-Hong Fang (Author), Huichang Bi (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liver regeneration is a complex process that involves the recruitment of bone marrow (BM)-derived hematopoietic stem and progenitor cells (HSPCs). Pregnane X receptor (PXR), also known as NR1I2, is an important regulator for liver enlargement and regeneration. However, the role of PXR activation in...