Internalisation and Biological Activity of Nucleic Acids Delivering Cell-Penetrating Peptide Nanoparticles Is Controlled by the Biomolecular Corona

• Main Authors: Annely Lorents (Author), Maria Maloverjan (Author), Kärt Padari (Author), Margus Pooga (Author)
• Format: Bog
• Udgivet: MDPI AG, 2021-07-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Nucleic acid molecules can be transferred into cells to alter gene expression and, thus, alleviate certain pathological conditions. Cell-penetrating peptides (CPPs) are vectors that can be used for transfecting nucleic acids as well as many other compounds. CPPs associate nucleic acids non-covalentl...