The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing-Induced Abnormal Behaviors in Mice

• Main Authors: Yukio Ago (Author), Ryota Araki (Author), Koji Yano (Author), Toshiyuki Kawasaki (Author), Shigeyuki Chaki (Author), Atsuro Nakazato (Author), Hirotaka Onoe (Author), Hitoshi Hashimoto (Author), Akemichi Baba (Author), Kazuhiro Takuma (Author), Toshio Matsuda (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity, aggression, and deficits of prepulse inhibition...