Population Pharmacokinetic Modeling and Simulation of TQ-B3101 to Inform Dosing in Pediatric Patients With Solid Tumors

• Main Authors: Fen Yang (Author), Huali Wu (Author), Yunhai Bo (Author), Ye Lu (Author), Hong Pan (Author), Su Li (Author), Qin Lu (Author), Simin Xie (Author), Harry Liao (Author), Bing Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: TQ-B3101 is a novel kinase inhibitor currently in development for the treatment of advanced malignant solid tumor and relapsed or refractory ALK-positive anaplastic large cell lymphoma.Methods: A population pharmacokinetic model was developed using data collected from a Phase 1 study and...