Chlorpromazine and Promethazine (C+P) Reduce Brain Injury after Ischemic Stroke through the PKC-δ/NOX/MnSOD Pathway

• Główni autorzy: Sichao Guo (Autor), Fengwu Li (Autor), Melissa Wills (Autor), James Yip (Autor), Alexandra Wehbe (Autor), Changya Peng (Autor), Xiaokun Geng (Autor), Yuchuan Ding (Autor)
• Format: Książka
• Wydane: Hindawi Limited, 2022-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Cerebral ischemia-reperfusion (I/R) incites neurologic damage through a myriad of complex pathophysiological mechanisms, most notably, inflammation and oxidative stress. In I/R injury, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) produces reactive oxygen species (ROS), which pro...