Interplay between RNA-binding protein HuR and Nox4 as a novel therapeutic target in diabetic kidney disease

• Main Authors: Qian Shi (Author), Doug-Yoon Lee (Author), Denis Féliers (Author), Hanna E. Abboud (Author), Manzoor A. Bhat (Author), Yves Gorin (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glomerular injury is a prominent pathological feature of diabetic kidney disease (DKD). Constitutively active NADPH oxidase 4 (Nox4) is a major source of reactive oxygen species that mediates hyperglycemia-induced mesangial cell (MC) fibrotic injury. However, the mechanism that Nox4 utili...