Covalent modification of nephrilin peptide with valproic acid increases its efficacy as a therapeutic in burn trauma

• मुख्य लेखकों: Desmond D. Mascarenhas (लेखक), Puja Ravikumar (लेखक), Edward P. Amento (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2020-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Introduction: Nephrilin peptide, a designed inhibitor of Rictor complex, modulates systemic responses to trauma, alleviating clinically relevant variables in a rat scald model and sepsis mortality in a mouse model. This study explores the possibility that chemical conjugation of small molecules to t...