Oxidative pentose phosphate pathway and glucose anaplerosis support maintenance of mitochondrial NADPH pool under mitochondrial oxidative stress

• Main Authors: Sun Jin Moon (Author), Wentao Dong (Author), Gregory N. Stephanopoulos (Author), Hadley D. Sikes (Author)
• פורמט: ספר
• יצא לאור: Wiley, 2020-09-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Abstract Mitochondrial NADPH protects cells against mitochondrial oxidative stress by serving as an electron donor to antioxidant defense systems. However, due to technical challenges, it still remains unknown as to the pool size of mitochondrial NADPH, its dynamics, and NADPH/NADP+ ratio. Here, we...