The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX

• Main Authors: Michael Kugler (Author), Josef Holub (Author), Jiří Brynda (Author), Klára Pospíšilová (Author), Suzan El Anwar (Author), Dmytro Bavol (Author), Miroslav Havránek (Author), Vlastimil Král (Author), Milan Fábry (Author), Bohumír Grüner (Author), Pavlína Řezáčová (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human carbonic anhydrase IX (CA IX), a protein specifically expressed on the surface of solid tumour cells, represents a validated target both for anticancer therapy and diagnostics. We recently identified sulfonamide dicarbaboranes as promising inhibitors of CA IX with favourable activities both in...