Synthesis of novel spirochromane incorporating Schiff's bases, potential antiproliferative activity, and dual EGFR/HER2 inhibition: Cell cycle analysis and in silico study

• Main Authors: Dina I.A. Othman (Author), Abdelrahman Hamdi (Author), Walaa M. Elhusseiny (Author), Adel S. El-Azab (Author), Ahmed H. Bakheit (Author), Mohamed Hefnawy (Author), Alaa A.-M (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Spirochromanes incorporating Schiff's bases and semicarbazones 4a-e and 5a-j were synthesizedand analyzed for their potential antiproliferative activity using four human cancer cell lines (MCF-7, HCT-116, PC3, and A549). Compounds 5a, 5b and 5g possessed the highest antiproliferative activity a...