NAC and Vitamin D Restore CNS Glutathione in Endotoxin-Sensitized Neonatal Hypoxic-Ischemic Rats

• Main Authors: Lauren E. Adams (Author), Hunter G. Moss (Author), Danielle W. Lowe (Author), Truman Brown (Author), Donald B. Wiest (Author), Bruce W. Hollis (Author), Inderjit Singh (Author), Dorothea D. Jenkins (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Therapeutic hypothermia does not improve outcomes in neonatal hypoxia ischemia (HI) complicated by perinatal infection, due to well-described, pre-existing oxidative stress and neuroinflammation that shorten the therapeutic window. For effective neuroprotection post-injury, we must first define and...