Novel Sunifiram-carbamate hybrids as potential dual acetylcholinesterase inhibitor and NMDAR co-agonist: simulation-guided analogue design and pharmacological screening

• Main Authors: Khalid A. Agha (Author), Nader E. Abo-Dya (Author), Abdul Rashid Issahaku (Author), Clement Agoni (Author), Mahmoud E. S. Soliman (Author), Eatedal H. Abdel-Aal (Author), Zakaria K. Abdel-Samii (Author), Tarek S. Ibrahim (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An efficient method for synthesising NMDAR co-agonist Sunifiram (DM235), in addition to Sunifram-carbamate and anthranilamide hybrids, has been developed in high yields via protecting group-free stepwise unsymmetric diacylation of piperazine using N-acylbenzotiazole. Compounds 3f, 3d, and 3i exhibit...