Pharmacokinetics, safety, and tolerability of BMS‐986263, a lipid nanoparticle containing HSP47 siRNA, in participants with hepatic impairment

• Main Authors: Hisham Qosa (Author), Claudia H. M. C. deOliveira (Author), Giovanni Cizza (Author), Eric J. Lawitz (Author), Nicholas Colletti (Author), Jeffrey Wetherington (Author), Edgar D. Charles (Author), Giridhar S. Tirucherai (Author)
• Format: Book
• Published: Wiley, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract BMS‐986263 is a retinoid‐conjugated lipid nanoparticle delivering small interfering RNA designed to inhibit synthesis of HSP47 protein, a collagen‐specific chaperone protein involved in fibrosis development. This is a phase I, open‐label, two‐part study evaluating pharmacokinetics and safet...