Pharmacokinetics, safety, and tolerability of BMS‐986263, a lipid nanoparticle containing HSP47 siRNA, in participants with hepatic impairment
Abstract BMS‐986263 is a retinoid‐conjugated lipid nanoparticle delivering small interfering RNA designed to inhibit synthesis of HSP47 protein, a collagen‐specific chaperone protein involved in fibrosis development. This is a phase I, open‐label, two‐part study evaluating pharmacokinetics and safet...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
| Published: |
Wiley,
2023-10-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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