Photoacoustic imaging reveals mechanisms of rapid-acting insulin formulations dynamics at the injection site

• Main Authors: Anjul Khadria (Author), Chad D. Paavola (Author), Konstantin Maslov (Author), Francisco A. Valenzuela (Author), Andrea E. Sperry (Author), Amy L. Cox (Author), Rui Cao (Author), Junhui Shi (Author), Patricia L. Brown-Augsburger (Author), Emmanuel Lozano (Author), Ross L. Blankenship (Author), Ranajoy Majumdar (Author), Scott A. Bradley (Author), John M. Beals (Author), Sunday S. Oladipupo (Author), Lihong V. Wang (Author)
• Format: Book
• Published: Elsevier, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Ultra-rapid insulin formulations control postprandial hyperglycemia; however, inadequate understanding of injection site absorption mechanisms is limiting further advancement. We used photoacoustic imaging to investigate the injection site dynamics of dye-labeled insulin lispro in the Hum...