Roux-en-Y gastric bypass surgery is effective in fibroblast growth factor-21 deficient mice

• Main Authors: Christopher D. Morrison (Author), Zheng Hao (Author), Michael B. Mumphrey (Author), R. Leigh Townsend (Author), Heike Münzberg (Author), Jianping Ye (Author), Hans-Rudolf Berthoud (Author)
• Format: Book
• Published: Elsevier, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The mechanisms by which bariatric surgeries so effectively and lastingly reduce body weight and normalize metabolic dysfunction are not well understood. Fibroblast growth fator-21 (FGF21) is a key regulator of metabolism and is currently considered for treatment of obesity. Although eleva...