Roux-en-Y gastric bypass surgery is effective in fibroblast growth factor-21 deficient mice

• Hlavní autoři: Christopher D. Morrison (Autor), Zheng Hao (Autor), Michael B. Mumphrey (Autor), R. Leigh Townsend (Autor), Heike Münzberg (Autor), Jianping Ye (Autor), Hans-Rudolf Berthoud (Autor)
• Médium: Kniha
• Vydáno: Elsevier, 2016-10-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Objective: The mechanisms by which bariatric surgeries so effectively and lastingly reduce body weight and normalize metabolic dysfunction are not well understood. Fibroblast growth fator-21 (FGF21) is a key regulator of metabolism and is currently considered for treatment of obesity. Although eleva...