IFI16 induces inflammation in hepatitis B virus-associated glomerulonephritis by regulating the Caspase-1/ IL-1 ß pathway

• Main Authors: Li Liu (Author), Shuangshuang Xie (Author), Cheng Li (Author), Yue Guo (Author), Xiaoyan Liu (Author), Xiuhua Zhao (Author), Qiang Li (Author), Wenjun Du (Author)
• Format: Book
• Published: BMC, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Aims and background IFI16 plays an important role in innate immunity against invasive microbial infection by sensing double-stranded DNA viruses due to caspase-1-dependent inflammasome activation and subsequent maturation and secretion of IL-1β. However, the role of IFI16 in regulating the...