Shikonin contributes to intestinal epithelial cell differentiation through PKM2/NRF2-mediated Polyol pathway

• Main Authors: Ling Huang (Author), Xiufu Tang (Author), FangYing Yang (Author), Wenxu Pan (Author), Xinhua Liang (Author), Zhaohui Xu (Author), Meiwan Cao (Author), Junhong Zhao (Author), Huan Chen (Author), Jing Huang (Author), Jiayu Chen (Author), Lanlan Geng (Author), Wanfu Xu (Author), Sitang Gong (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Alteration of polyol pathway is a critical event in serials of disease, including inflammatory bowel disease (IBD). Shikonin, an inhibitor of PKM2, has been reported to exert a wide range of biological and pharmacological properties. However, the function of shikonin-mediated polyol path...