Comparison of the Blood-Brain Barrier Transport and Vulnerability to P-Glycoprotein-Mediated Drug-Drug Interaction of Domperidone versus Metoclopramide Assessed Using In Vitro Assay and PET Imaging

Comparison of the Blood-Brain Barrier Transport and Vulnerability to P-Glycoprotein-Mediated Drug-Drug Interaction of Domperidone versus Metoclopramide Assessed Using In Vitro Assay and PET Imaging

Domperidone and metoclopramide are widely prescribed antiemetic drugs with distinct neurological side effects. The impact of P-glycoprotein (P-gp)-mediated efflux at the blood-brain barrier (BBB) on brain exposure and BBB permeation was compared in vitro and in vivo using positron emission tomograph...

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Main Authors: Louise Breuil (Author), Sébastien Goutal (Author), Solène Marie (Author), Antonio Del Vecchio (Author), Davide Audisio (Author), Amélie Soyer (Author), Maud Goislard (Author), Wadad Saba (Author), Nicolas Tournier (Author), Fabien Caillé (Author)
Format: Book
Published: MDPI AG, 2022-08-01T00:00:00Z.
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3rd Floor Main Library

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